Methoxy polyethylene glycol epoetin beta and the treatment of anaemia in chronic heart failure
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چکیده
منابع مشابه
Methoxy polyethylene glycol-epoetin beta for anemia with chronic kidney disease
Chronic kidney disease (CKD) is a risk factor for end-stage renal failure and cardiovascular events. In patients with CKD, anemia is often caused by decreased erythropoietin production relative to hemoglobin levels. As correction of anemia is associated with improved cardiac and renal function and quality of life, erythropoiesis-stimulating agents (ESAs) are standard therapy for anemia in CKD p...
متن کاملEffects of treatment with epoetin beta on outcomes in patients with anaemia and chronic heart failure.
UNLABELLED Anaemia is frequently found in patients with chronic heart failure (CHF) and has been associated with an increase in mortality and morbidity, impaired cardiac and renal function and a reduced quality of life (QoL) compared with non-anaemic CHF patients. Correction of anaemia with recombinant human erythropoietin (epoetin) has been associated with an improvement in CHF in both control...
متن کاملEffect of methoxy polyethylene glycol-epoetin beta on oxidative stress in predialysis patients with chronic kidney disease
BACKGROUND There is data in the literature indicating increased oxidative stress in chronic kidney disease (CKD). Erythropoiesisstimulating agents (ESAs), which are commonly used to treat anemia in patients with CKD, seem to have an antioxidant action, which could be a part of nephroprotection. The aim of the current study was to investigate the effect of a long half-life ESA, methoxy polyethyl...
متن کاملMaintenance treatment of renal anaemia in haemodialysis patients with methoxy polyethylene glycol-epoetin beta versus darbepoetin alfa administered monthly: a randomized comparative trial
BACKGROUND Several studies with erythropoiesis-stimulating agents claim that maintenance therapy of renal anaemia may be possible at extended dosing intervals; however, few studies were randomized, results varied, and comparisons between agents were absent. We report results of a multi-national, randomized, prospective trial comparing haemoglobin maintenance with methoxy polyethylene glycol-epo...
متن کاملMIRCERA, methoxy polyethylene glycol-epoetin beta, is an ESA which differs from erythropoietin through formation of a chemical bond between an amino group present in erythropoietin beta and methoxy polyethylene glycol (PEG) butanoic acid. MIRCERA
There is a global increase in the number of patients with CKD. Data from the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) registry, in which roughly 80% of patients were on haemodialysis (HD) and 20% on peritoneal dialysis (PD), showed that the incidence of renal replacement therapy for ESRD had risen from 79 per million population (pmp) in 1990 to 117 pmp ...
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ژورنال
عنوان ژورنال: Russian Journal of Cardiology
سال: 2013
ISSN: 1560-4071
DOI: 10.15829/1560-4071-2013-3-74-80